Studyhazard statement category 1 category 2 category 3 category 4 category 5. Acute shortterm exposure of humans and animals to propylene oxide has caused eye and respiratory tract irritation. Department of transportation hazard labels, and a general description of the chemical. Propylene oxide po was first prepared in 1861 by oser, and first polymerized by levene and walti in 1927 1.
The red and supporting documents for propylene glycol and dipropylene glycol will be available. Acetyl groups in food starchmodified not to exceed 2. Box 4980 the woodlands, tx 77387 telephone numbers transportationemergency chemtrec. It is a chiral epoxide, although it is commonly used as a racemic mixture.
Firefighting measures promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. Calibrate daily with at least six working standards over the range 0. Our msds database is an easy to use, do it yourself tool, and best of all. Propylene oxide is a directacting sn2 alkylating agent, and in reactions with nucleosides and dna, it forms 2hydroxypropyl adducts at n1 and n3 of adenine, n7 of guanine, n3 of cytosine, and n3 of thymine albertini and sweeney 2007. Never use direct flame or electrical heating devices to raise the pressure of a container. Use only nonsparking tools and equipment in the cleanup process. Move containers from fire area if this can be done without risk. Propylene oxide is also used as a reactant to produce alkanol amines from ammonia or amines and as an intermediate in the production of allyl alcohol. Propylene oxide 75569 2008792 0 1 osha regulatory status. The heat release in the primary flame cone is slightly less than that of acetylene. When compared with acetylene, it has moderate btu capacity in its primary and high btu capacity in its secondary flames. Propylene dichloride 1,2dichloropropane 78875 hazard summary propylene dichloride is used as a chemical intermediate in several industries. Propylene oxide splashed in the eye can cause severe burning, tearing, redness, swelling and corneal burns, propylene oxide vapors also can cause.
Sign up and be the first to learn about new products for your laboratory and product specials. Volatilization of propylene oxide from the aquatic environment may be an important transport mechanism. Residual propylene chlorohydrin not more than 5 parts per million in food starchmodified. Propylene oxide pro or po is utilized primarily as a chemical intermediate in the manufacture of items such as flexible and rigid foams, elastomers, coatings, adhesives, and injection moldingsall of which can be seen in a variety of products, including tubshower combinations, gasoline tanks, and boat hulls. Propylene oxide, 2 ppm twa, 400 ppm idlh, 100 ppm twa.
Propylene oxide reacts with water to produce propylene glycol 57556, dipropylene glycol, tripropylene. This website and underlying databases are maintained and updated by pesticide action network north america pan. Propylene oxide propylene oxide 75569 methyloxirane, 1,2epoxypropane is a significant organic chemical product used primarily as a reaction intermediate for production of polyether polyols, propylene. Propylene oxide also reacts with water to form back to top product uses12, propylene oxide is an intermediate used in the manufacture of a wide variety of important chemical products such as. Safety data sheet propylene polymer grade, unodorized version 1. Add known amounts of pro or calibration stock solution to cs 2 in 10ml volumetric flasks and dilute to the mark. Ethylene propylene diene monomer epdm rubber final 29june2006 fraction. Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. En close container valve after each use and when empty, even if still connected to equipment.
Prolonged exposure to vapor of even low concentrations can result in nausea and vomiting. The acute toxicity of propylene oxide has been investigated orally median lethal doses ld. Propylene oxide in liquid or solid solution form may be absorbed through the skin and produce toxic effects. See working with the information on this page section below for important notes about this data. Propylene oxide handling and storage considerations tech. Composition information on ingredients ingredients cas number einecs number % by weight oxirane, homopolymer 2085998 nl 45 50 calcium carbonate 17653 2152796 15 20. Propylene oxide and propylene oxide monitoring interscan. This colourless volatile liquid with an odour resembling ether, is produced on a large scale industrially.
When the target gas or substance is unknown our specialty hazmat kits provide an excellent answer for quick identification and measurement. Identification of the substancemixture and of the companyundertaking 1. Plastic bottle may burn and give off oxides of carbonnitrogen. High concentrations may produce irritation of the eyes, lungs, and mucous membranes. About 21% of these are agrochemical intermediates, 20% are dyestuff intermediates, and 25% are pharmaceutical intermediates. Methylene chloride has been shown to increase the rate of malignant tumors in laboratory animals. No action shall be taken involving any personal risk or without suitable training. Propylene oxide handling and storage considerations technical bulletin page 3 of 4 propylene oxide should be stored, handled, or used only in well ventilated areas. Cdc niosh pocket guide to chemical hazards propylene oxide. Occupational exposure limits, if available, are listed in section 8. The information in cameo chemicals comes from a variety of data sources. Because the pel for ethylene oxide, which is chemically similar to propylene oxide and is also an animal carcinogen, has recently been reduced to 1 ppm ref.
Product data and technical information corporate statement. The chemical identifier fields include common identification numbers, the nfpa diamond u. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Propylene oxide is an organic compound with the molecular formula ch 3 chch 2 o. Determine impurities in highpurity propylene oxide with. The manual is not intended to be a howto manual, nor is it a prescriptive guide. Contain and absorb spilled liquid with noncombustible, inert absorbent material e. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Ventilation equipment should be explosionresistant if explosive concentrations of material are present. If released to the atmosphere, propylene oxide will react in the vapor phase with photochemically produced hydroxyl radicals with an estimated halflife of approximately 30 days. Propylene c3h6 is a colorless, flammable, liquefied gas with a faintly sweet odor. Methyloxirane, 12 epoxypropane, methyl ethylene oxide, propylene epoxide. As part of the red, the agency has determined that propylene glycol and dipropylene. P4648 410 this document is only controlled while on the praxair, inc.
Propylene oxide 75569 hazard summary propylene oxide is used in the production of polyethers the primary component of polyurethane foams and propylene glycol. Poloxamer 181, surfactant may contain trace amounts of ethylene oxide, propylene oxide, and 1,4dioxane. May react with oxygen and strong oxidizing agents, such as chlorates, nitrates, peroxides, etc. Propylene oxide is a colorless, lowboiling and highly volatile liquid with a sweet ether propylene oxide reacts readily with alcohols, amines, and acids. A wide variety of propylene oxide price options are available to you. Based on evidence that propylene oxide is an animal carcinogen, niosh recommends that occupational exposure to propylene oxide be reduced to the lowest feasible level.
Helmer scientific is a fda gmp and iso485 compliant manufacturer of medical devices. Dermal contact, even with dilute solutions, has caused skin. Substance any concentration shown as a range is to protect confidentiality or is due to batch. Method 1612, issue 2, dated 15 august 1994 page 3 of 4 calibration and quality control. Individual companies may need to vary approaches to particular practices described. It became an important basic raw material that can be used in a wide range of industrial and commercial products. Propylene oxide 75569 propylene oxide have been listed as potential carcinogens by irac. Lyondellbasell is the worlds leading producer of propylene oxide po, a commodity chemical used in the manufacturing of thousands of everyday products, ranging from antifreeze to cosmetics. This material is classified as hazardous under osha regulations. Repeated exposure can result in significant skin absorption.
Pesticides reregistration eligibility decision for propylene glycol. Material safety data sheet validation date product and company identification 1. Propylene oxide lyondellbasell industries lyondellbasell. Acute shortterm inhalation exposure to high levels of propylene dichloride by humans results in effects on the lungs, gastrointestinal system, blood, liver, kidneys, central nervous system, and eyes. Propylene oxide urethane grade pdf, 38kb propylene oxide handling pdf, 38kb huntsman internationals state of the art propylene oxide po production facility utilizes proprietary technology to produce po and coproduct methyl tertiary butyl ether mtbe. Sds of propylene oxide, safety data sheets, cas 75569. Propylene glycol dinitrate is the explosive part of otto fuel ii. This information was obtained from a material safety data sheet on. Box 550 1560 industry road hatfield, pa 19440 phone. Instability and reactivity hazards propylene oxide is a stable material that will not decompose under normal conditions of temperature and pressure. Handling and storage advice on general occupational hygiene conditions for safe storage, including any incompatibilities eating, drinking and smoking should be prohibited in areas where this material is. Its major application is its use for the production of polyether polyols for use in making polyurethane plastics. Propylene oxide is an irritant to skin, respiratory tract and eyes.
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